Roles of Cellular Respiration, Cg CDR1 , and Cg CDR2 in Candida glabrata Resistance to Histatin 5
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منابع مشابه
Using PCR to Compare the Expression of CDR1, CDR2, and MDR1 in Candida Albicans Isolates Resistant and Susceptible to Fluconazole
Abstract Background and objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of ERG11 and the expression of CDR1, CDR2, and MDR1. This study aimed to compare the ex...
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BACKGROUND The opportunistic fungi, particularly Candida glabrata has been known as main etiologic agents of life-threating infections in some patients. Although fluconazole is the most effective antifungal agent against candidiasis, C. glabrata, fluconazole-resistant strains have been increased recently overexpression or mutations of ATP-binding cassette (ABC) transporter family membrane prote...
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From a mosaic of rather deep V and I images of the CG 30/CG 31 region we report distances and absorptions of these and other interesting interstellar features, the distances and absorptions estimates are based on shifting a new (V−I) 0 – M V relation obtained from nearby, presumably unreddened Hipparcos stars with luminosity class V classification to fit confining trends in the (V−I) – V diagra...
متن کاملA mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans.
TAC1, a Candida albicans transcription factor situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance. We showed previously the existence of both wild-type and hyperactive TAC1 alleles. Wild-type alleles mediate upregulation of CDR1 and CDR2 upon exposure to inducers such as fluphenazine, w...
متن کاملOverexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
The micafungin and caspofungin susceptibilities of Candida albicans laboratory and clinical isolates and of Saccharomyces cerevisiae strains stably hyperexpressing fungal ATP-binding cassette (ABC) or major facilitator superfamily (MFS) transporters involved in azole resistance were determined using three separate methods. Yeast strains hyperexpressing individual alleles of ABC transporters or ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2006
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.50.3.1100-1103.2006